Radiotherapy-Induced Sarcoma - A Clinical Case Report
Autores
Mariana Soares Duarte, Daniel Osório, JM Preza Fernandes, Susana Marta, Tânia Teixeira, Cláudia Paiva, Tomé Pereira, José Polónia
Resumo Introdução
A rare but severe complication of radiation therapy for breast cancer is radiation-induced sarcoma of the breast, appearing years after the original course of treatment. This report describes a case of breast sarcoma in a previously irradiated field, highlighting the diagnostic and therapeutic challenges.
Resumo Métodos
This report describes a case of breast sarcoma that emerged in a previously irradiated field, highlighting the diagnostic and therapeutic challenges.
Resumo Resultados
A 76-year-old woman who had undergone conservative surgery and adjuvant radiation treatment for left-sided breast cancer six years earlier now had a new lump in the same breast. A 2 cm heterogeneous lesion within the previously irradiated tissue was shown by imaging, including a CT scan. The diagnosis of an angiosarcoma was confirmed by core biopsy. Radiotherapy-induced sarcoma was diagnosed based on clinical history, imaging features, histopathology and clinical criteria as prior history of radiation exposure, tumor within a previously irradiated field, a development within the latency period and histological confirmation of sarcoma. The patient underwent a radical mastectomy with clear surgical margins.
Resumo Discussão
Because early detection has substantial impact on outcomes, this case highlights the importance of being vigilant in long-term breast cancer survivors who have received radiation therapy. Because of their rarity, breast sarcomas caused by radiation therapy are difficult to diagnose and require a multidisciplinary approach.