How is Gastrointestinal Quality of Life after Cytoreductive Surgery and HIPEC - a Unicenter Prospective Study
Autores
Maria João Madeira-Cardoso, Mariana Peyroteo, André Guimarães, Mariana Marques, Paula Pinto, Alexandre Sousa, Manuel Fernandes, Fernanda Sousa, Joaquim Abreu de Sousa
Resumo Introdução
CRS+HIPEC is a major procedure, including, many times, gastrointestinal resections (GIR). QoL significantly decreases over the 3-6months after CRS+HIPEC and increases up to the basal level 6-12months after that. No prospective studies are published. Aim: to prospectively analyze the impact of CRS+HIPEC in GI QoL
Resumo Métodos
Prospective unicenter review of all patients submitted to CRS+HIPEC with curative intent since June2023-September2024. All answered the Gastrointestinal Quality of Life Index (GIQLI) (from 0-144 best score) and EORTCQLQ before CRS+HIPEC (basal QoL), 3, 6 and 12months after surgery. The impact of GIR was evaluated. Exclusion criteria: CC>1 and <3months follow-up.
Resumo Resultados
60 patients admitted to CRS+HIPEC. 11 excluded. N = 49, 64.4% female, mean age 59?13 years, CC0 91.7%, GIR 62.5%. Basal median GIQLI score 132, IQR 112, GIQLI-3months score 120, IQR 102, GIQLI-6months 127, IQR 114, GIQLI-12months 129, IQR 94. GI QoL significantly decreases from basal to 3months after CRS+HIPEC(p<0.001), even when there was no GIR(p>0.05). GI QoL significantly increases from 3-6months after CRS+HIPEC(p<0.001). There is no difference between basal GI QoL and 12months after surgery(p>0.05). The same tendency is reflected among EORTC scores although diarrhea is worse after GIR.
Resumo Discussão
Despite the decrease in GI QoL 3months after CRS+HIPEC, GI QoL increases up to basal levels over a year even in GIR. Conclusion: CRS+HIPEC has apparently no negative impact on GI QoL after 3months.